Neonatal rubella myocarditis.
نویسندگان
چکیده
Teratogenicity ofthe rubella virus for the developing organ systems of the human embryo has been recognized since Gregg's (1941) clinical description of the congenital rubella syndrome and the retrospective epidemiological investigation of the 1940 Australian rubella epidemic by Swan et al. (1943). Pathogenesis, however, remained speculative, as rubella was only of presumed viral etiology. Subsequent retrospective and prospective studies established the congenital rubella syndrome as a well-defined clinical entity (Greenberg, Pellitteri, and Barton, 1957; Ingalls, 1957; Lundstrom, 1962; Michaels and Mellin, 1960; Tartakow, 1965; Wesselhoeft, 1949). Laboratory identification and propagation of the rubella virus was reported simultaneously by Weller and Neva (1962) and by Parkman, Buescher, and Artenstein (1962). The viral etiology of rubella had been confirmed. Selzer (1963) demonstrated this virus in the placenta, amniotic fluid, and foetal tissues of an infected human abortus, thereby confirming that teratogenicity of this virus was the result of infection of tissues during the vital period of organogenesis. This was a fortuitous sequence of events, because rubella occurred in almost pandemic proportions in the United States of America during 1964. The epidemic originated in the New England States and then swept south and west to the Rocky Mountains where it stopped, sparing the Intermountain and Pacific Coast States. A large number of afflicted infants were born and numerous groups throughout the United States reported their experience with the congenital rubella syndrome during this epidemic. In addition to extending the clinical description of the syndrome, three observations of extreme im-
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ورودعنوان ژورنال:
- British heart journal
دوره 28 5 شماره
صفحات -
تاریخ انتشار 1966